Interaction of morphine- and codeine-epoxides with opiate receptor.
نویسندگان
چکیده
منابع مشابه
Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
A series of 3-O-acyl-6-O-sulfate esters of morphine, dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several compounds exhibited good affinity for the mu-opiate receptor. Morphine-3-O-propionyl-6-O-sulfate had four times greater affinity than morphin...
متن کاملComparison of the EMIT (enzyme multiplied immunoassay technique) opiate assay and a gas-chromatographic--mass-spectrometric determination of morphine and codeine in urine.
We examined 124 urine samples with the EMIT opiate assay kit and with a gas-chromatographic-mass-spectrometricdetermination (I) for morphine and codeine. With a cut-off value between positive and negative resultsat0.5 mg (morphine equivalents)per liter for both methods, the EMIT assay gave 4.0% falsepositivesand 5.6% false negativeswhen compared with I. Lowering of the cut-off value for Ito 0.1...
متن کاملSensitivity, specificity, and efficiency in detecting opiates in oral fluid with the Cozart Opiate Microplate EIA and GC-MS following controlled codeine administration.
Oral fluid specimens (N = 1406) were collected from 19 subjects prior to and up to 72 h following controlled administration of oral codeine. Volunteers provided informed consent to participate in this National Institute on Drug Abuse Institutional Review Board-approved protocol. A modification of Cozart Microplate Opiate EIA Oral Fluid Kit (Opiate ELISA), employing codeine calibrators, was used...
متن کاملConcentrations of Morphine and Codeine in Paired Oral Fluid and Urine Specimens Following Ingestion of a Poppy Seed Roll and Raw Poppy Seeds
Interpretation of opiate drug test results can be challenging due to casual dietary consumption of poppy seeds, which may contain variable opiate content. Opiate concentrations in paired oral fluid (OF), collected with the Oral-Eze(®) Oral Fluid Collection System, and urine were analyzed after ingestion of poppy seeds from the same source, consumed raw or contained in a roll. In Part 1, 12 indi...
متن کاملOpiate-like substances in an invertebrate, an opiate receptor on invertebrate and human immunocytes, and a role in immunosuppression.
The presence of morphine-like and codeine-like substances was demonstrated in the pedal ganglia, hemolymph, and mantle tissues of the mollusc Mytilus edulis. The pharmacological activities of the endogenous morphine-like material resemble those of authentic morphine. Both substances were found to counteract, in a dose-dependent manner, the stimulatory effect of tumor necrosis factor alpha or in...
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ورودعنوان ژورنال:
- Japanese journal of pharmacology
دوره 33 6 شماره
صفحات -
تاریخ انتشار 1983